Publications

B Zaharija & NJ Bradshaw "Aggregation of Disrupted in Schizophrenia 1 arises from a central region of the protein" Progress in Neuro-Psychopharmacology & Biological Psychiatry (2024) 130 110923

B Zaharija*, M Odorčić*, A Hart, B Samardžija, R Marreiros, I Prikulis, M Juković, TM Hyde, JE Kleinman, C Korth & NJ Bradshaw, “TRIOBP-1 protein aggregation exists in both major depressive disorder and schizophrenia, and can occur through two distinct regions of the protein” International Journal of Molecular Sciences (2022) 23 (19) 11048

B Samardžija*, A Pavešić Radonja*, B Zaharija, M Bergman, É Renner, M Palkovits, G Rubeša & NJ Bradshaw, "Protein aggregation of NPAS3, implicated in mental illness, is not limited to the V304I mutation" Journal of Personalized Medicine (2021) 11 1070 

B Zaharija, B Samardžija & NJ Bradshaw, "The TRIOBP isoforms and their distinct roles in actin stabilization, deafness, mental illness, and cancer" Molecules (2020) 25 4967

NJ Bradshaw & C Korth, “Protein misassembly and aggregation as potential convergence points for non-genetic causes of chronic mental illness” Molecular Psychiatry (2019) 24 (7) 936-951

NJ Bradshaw, L Ukkola-Vuoti, M Pankakoski, AB Zheutlin, A Ortega-Alonso, M Torniainen-Holm, V Sinha, S Therman, T Paunio, J Suvisaari, J Lönnqvist, TD Cannon, J Haukka & W Hennah, “The NDE1 genomic locus affects treatment of psychiatric illness through gene expression changes related to microRNA-484”, Open Biology (2017) 7 170153

NJ Bradshaw, “The interaction of schizophrenia-related proteins DISC1 and NDEL1, in light of the newly identified domain structure of DISC1” Communicative and Integrative Biology (2017) 8 (4) e1335375

Previous publications by lab members:

NJ Bradshaw, SV Trossbach, S Köber, S Walter, I Prikulis, S Weggen & C Korth, “Disrupted-in-Schizophrenia 1 regulates the processing of reelin in the perinatal cortex” Schizophrenia Research (2020) 215 506-513

ASK Yerabham, A Müller-Schiffmann, T Ziehm, A Stadler, S Köber, X Indurkya, R Marreiros, SV Trossbach, NJ Bradshaw, I Prikulis, D Willbold, OH Weiergräber & C Korth, “Biophysical insights from a single chain antibody directed against the disrupted in schizophrenia 1 protein”, PLOS One (2018) 13 (1) e0191162

J Giacometti, Č Milan, M Čuk, B Samardžija & B Radošević-Stašić, “Partial hepatectomy and diets enriched with olive and corn oil altered the phospholipid fatty acid profile in the spleen”, Journal of Nutrition and Food Science Forecast (2018) 1 (1) e1005

NS Gowert, I Krüger, M Klier, L Donner, F Kipkeew, M Gliem, NJ Bradshaw, D Lutz, S Köber, H Langer, S Jander, K Jurk, M Frotscher, C Korth, HH Bock & M Elvers, “Loss of reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions” Cellular Signalling (2017) 40 210-221

NJ Bradshaw, ASK Yerabham, R Marreiros, T Zhang, L Nagel-Steger & C Korth, “An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure” Journal of Biological Chemistry (2017) 292 (23) 9583-9598

ASK Yerabham, PJ Mas, C Decker, DC Soares, OH Weiergräber, L Nagel-Steger, D Willbold, DJ Hart, NJ Bradshaw & C Korth, “A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions which are bisected by mental illness-related mutations” Journal of Biological Chemistry (2017) 292 (16) 6468-6477

NJ Bradshaw & MAF Hayashi, “NDE1 and NDEL1 from genes to (mal)functions: Parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness” Cellular and Molecular Life Sciences (2017) 74 (7) 1191-1210

NJ Bradshaw, “Cloning of the promoter of NDE1, a gene implicated in psychiatric and neurodevelopmental disorders through copy number variation” Neuroscience (2016) 324 262-270

NJ Bradshaw, V Bader, I Prikulis, A Lueking, S Müllner & C Korth, “Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia” PLOS One (2014) 9 (10) e111196

NJ Bradshaw, W Hennah & DC Soares, “NDE1 and NDEL1: Twin neurodevelopmental proteins with similar "nature" but different "nurture"” Biomolecular Concepts (2013) 4 (5) 447-464

ASK Yerabham, OH Weiergräber, NJ Bradshaw & C Korth, “Revisiting Disrupted in Schizophrenia 1 as a scaffold protein” Biological Chemistry (2013) 394 (11) 1425-1437

DC Soares, NJ Bradshaw, J Zou, CK Kennaway, RS Hamilton, ZA Chen, MA Wear, EA Blackburn, J Bramham, B Böttcher, JK Millar, PN Barlow, MD Walkinshaw, J Rappsilber & DJ Porteous, “The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers and polymers with a folded-back structure in solution” Journal of Biological Chemistry (2012) 287 (39) 32381-32393

V Bader, L Tomppo, SV Trossbach, NJ Bradshaw, I Prikulis, SR Leliveld, C-Y Lin, K Ishizuka, A Sawa, A Ramos, I Rosa, Á García, JR Requena, M Hipolito, N Rai, E Nwulia, U Henning, S Ferrea, C Luckhaus, J Ekelund, J Veijola, M-R Järvelin, W Hennah & C Korth, “Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits” Human Molecular Genetics (2012) 21 (29) 4406-4418

JE Eykelenboom, GJ Briggs, NJ Bradshaw, DC Soares, F Ogawa, S Christie, ELV Malavasi, P Makedonopoulou, S Mackie, MP Malloy, MA Wear, EA Blackburn, J Bramham, AM McIntosh, DH Blackwood, WJ Muir, DJ Porteous & JK Millar, “A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered,
deleterious mitochondrial proteins” Human Molecular Genetics (2012) 21 (15) 3374-3386

NJ Bradshaw & DJ Porteous, “DISC1-binding proteins in neural development, signalling and schizophrenia” Neuropharmacology (2012) 62 (3) 1230-1241

NJ Bradshaw, DC Soares, BC Carlyle, F Ogawa, H Davidson-Smith, S Christie, S Mackie, PA Thomson, DJ Porteous & JK Millar, “PKA phosphorylation of NDE1 is DISC1/PDE4-dependent and modulates its interaction with LIS1 and NDEL1”, Journal of Neuroscience (2011) 31 (24) 9043-9054

DC Soares, BC Carlyle, NJ Bradshaw & DJ Porteous, “DISC1: structure, function and therapeutic potential for major mental illness” ACS Chemical Neuroscience (2011) 2 (11) 609-632

DJ Obbard, FM Jiggins, NJ Bradshaw & TJ Little, “Recent and recurrent selective sweeps of the antiviral RNAi gene Argonaute-2 in three species of Drosophila”, Molecular Biology and Evolution (2011) 28 (2) 1043-1056

T Grahovac, K Ružić, D Šepić-Grahova, E Dadić-Hero & A Pavešić Radonja “Depressive disorder and alopecia” Psychiatria Danubina (2010) 22 (2) 293-295

A Pavešić Radonja, K Ružić & T Grahovac “Psychogenic dystonia – Case report” Psychiatria Danubina (2010) 22 (2) 289-292

T Grahovac, K Ružić, P Medved, A Pavešić-Radonja, E Dadić-Hero, “Hyperprolactinaemia – a risperidone side-effect”, Psychiatria Danubina (2010) 22 (1) 120-122

NJ Bradshaw, S Christie, DC Soares, BC Carlyle, DJ Porteous & JK Millar, “NDE1 and NDEL1: Multimerisation, alternate splicing and DISC1 interaction”, Neuroscience Letters (2009) 449 (3) 228-233

NJ Bradshaw, F Ogawa, B Antolin-Fontes, JE Chubb, BC Carlyle, S Christie, A Claessens, DJ Porteous & JK Millar, “DISC1, PDE4B and NDE1 at the centrosome and synapse”, Biochemical and Biophysical Research Communications (2008) 377 (4) 1091-1096

JE Chubb, NJ Bradshaw, DC Soares, DJ Porteous & JK Millar, “The DISC locus in psychiatric illness”, Molecular Psychiatry (2008) 13 (1) 36-64